How truly "safe" is a file or prog if the .exe is partially flagged as positive for malware by Virus Total?

2    22 May 2017 16:13 by u/MustaphaMonde

Theoretically speaking of course, say you have a file or little proggy that Virus Total flags 10/60 (obscure AV positives). Why does one antivirus consider a file or program malicious and another doesn't?
BTW, I am not a programmer

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10/60 is pretty high. Are they hueristic matches? Are any of the 10 from a well known virus scanner?